Actress Marlo Thomas, who fronts the all-star campaign that raises millions for the medical centre, has revealed the mother told her about how Aniston's message helped her to get the right diagnosis for her sick daughter.
Thomas tells WENN, ""Jennifer Aniston has been with us from the beginning - nine years. She does these PSAs which are wonderful. They tell the stories of children and what they've been through.
""In fact I had a mother come up to me the other day to tell me that Jennifer Aniston saved her daughter's life. The disease that Jennifer was talking about on the PSA was what this little girl had. Her mother recognised it as the same symptoms and demanded the doctor give her daughter an MRI, and in fact she did have that brain tumour.
""They're not vanity spots; they're really informative and there to give information.""